584 Dandruff is associated with perturbations of hair follicle immune privilege, and the infundibular and epidermal immune microenvironment

Dandruff is a common scalp condition. The immune-microenvironment of dandruff skin remains poorly characterised and the hair follicle’s physiological immune privilege (HF IP) status in completely unknown. We hypothesised that latter might be important context dandruff-associated inflammation as HF IP expected to impact on overall immunophysiology. analysed expression biomarkers (CD200, MHC class I, β2M, II) guardians (α-MSH MIF), quantified intra- perifollicular cells (CD4, CD8 CD68) healthy versus (non-lesional lesional) biopsies by quantitative immunohistomorphometry(n= 5-8). Class I protein was increased proximal outer root sheath (ORS) non-lesional lesional HFs, while β2M ORS HFs bulge HFs. CD200 unaltered. locally produced potent immunoinhibitory guardian, MIF, decreased infundibulum, bulge, α-MSH Langerhans cells, labelled intraepithelial II+ staining, were infundibulum (p<0.01). In epidermis, CD4+ CD8+ T significantly (p<0.0001). number CD68+ Macrophages, remained unchanged Together, this work presents first evidence associated with weakened IP, reduction epidermal infiltration cells.